![Novelty Nobility Challenges “Development of an AMD Therapeutic Agent with a New Mechanism, c-KIT” - 바이오스펙테이터 Novelty Nobility Challenges “Development of an AMD Therapeutic Agent with a New Mechanism, c-KIT” - 바이오스펙테이터](http://img.etoday.co.kr/pto_db/2019/09/400/20190920103447_1368034_904_609.jpg)
Novelty Nobility Challenges “Development of an AMD Therapeutic Agent with a New Mechanism, c-KIT” - 바이오스펙테이터
![A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis - ScienceDirect A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0027510701001178-gr2.jpg)
A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis - ScienceDirect
![IJMS | Free Full-Text | Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST) IJMS | Free Full-Text | Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST)](https://www.mdpi.com/ijms/ijms-24-05411/article_deploy/html/images/ijms-24-05411-g001.png)
IJMS | Free Full-Text | Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST)
![Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms: Molecular Therapy Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms: Molecular Therapy](https://www.cell.com/cms/attachment/b2b21a84-a8f2-4661-b142-4c61f159e260/fx1.jpg)
Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms: Molecular Therapy
Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity | PLOS Computational Biology
![The D816V mutation in the catalytic domain of the c-Kit receptor downstream tyrosine kinase in peripheral blood mononuclear cells (by M. Niedoszytko). The D816V mutation in the catalytic domain of the c-Kit receptor downstream tyrosine kinase in peripheral blood mononuclear cells (by M. Niedoszytko).](https://s3-eu-west-1.amazonaws.com/ppreviews-plos-725668748/2631302/preview.jpg)
The D816V mutation in the catalytic domain of the c-Kit receptor downstream tyrosine kinase in peripheral blood mononuclear cells (by M. Niedoszytko).
![Schematic diagram of c-kit tyrosine kinase receptor. The most common... | Download Scientific Diagram Schematic diagram of c-kit tyrosine kinase receptor. The most common... | Download Scientific Diagram](https://www.researchgate.net/publication/266091193/figure/fig3/AS:644264639856640@1530616068365/Schematic-diagram-of-c-kit-tyrosine-kinase-receptor-The-most-common-mutations.png)
Schematic diagram of c-kit tyrosine kinase receptor. The most common... | Download Scientific Diagram
Role and significance of c-KIT receptor tyrosine kinase in cancer: A review | Biomolecules and Biomedicine
![Cancers | Free Full-Text | KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer Cancers | Free Full-Text | KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer](https://www.mdpi.com/cancers/cancers-14-02781/article_deploy/html/images/cancers-14-02781-g006.png)
Cancers | Free Full-Text | KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer
![Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis | Scientific Reports Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fsrep13718/MediaObjects/41598_2015_Article_BFsrep13718_Fig1_HTML.jpg)
Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis | Scientific Reports
![A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth | Journal of Cancer Research and Clinical Oncology A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth | Journal of Cancer Research and Clinical Oncology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00432-020-03490-6/MediaObjects/432_2020_3490_Fig4_HTML.png)