![Original SARS-CoV-2 monovalent and Omicron BA.4/BA.5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results | Nature Medicine Original SARS-CoV-2 monovalent and Omicron BA.4/BA.5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results | Nature Medicine](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41591-023-02517-y/MediaObjects/41591_2023_2517_Fig1_HTML.png)
Original SARS-CoV-2 monovalent and Omicron BA.4/BA.5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results | Nature Medicine
![Moderna says updated booster generated 'significantly higher' neutralizing antibodies against BA.4/BA.5 subvariants - ABC7 Chicago Moderna says updated booster generated 'significantly higher' neutralizing antibodies against BA.4/BA.5 subvariants - ABC7 Chicago](https://cdn.abcotvs.com/dip/images/12452257_moderna-generic-TN-img.jpg)
Moderna says updated booster generated 'significantly higher' neutralizing antibodies against BA.4/BA.5 subvariants - ABC7 Chicago
![Moderna on X: "In a Phase 2/3 trial in over 500 adults, mRNA-1273.222, induced significantly higher neutralizing antibody titers against BA.4/BA.5 compared to a booster dose of mRNA-1273. Read more: https://t.co/CPnxL03nZW https://t.co/ODihw6qtsQ" / Moderna on X: "In a Phase 2/3 trial in over 500 adults, mRNA-1273.222, induced significantly higher neutralizing antibody titers against BA.4/BA.5 compared to a booster dose of mRNA-1273. Read more: https://t.co/CPnxL03nZW https://t.co/ODihw6qtsQ" /](https://pbs.twimg.com/media/Fhhqz2NWAAInpLU.jpg)
Moderna on X: "In a Phase 2/3 trial in over 500 adults, mRNA-1273.222, induced significantly higher neutralizing antibody titers against BA.4/BA.5 compared to a booster dose of mRNA-1273. Read more: https://t.co/CPnxL03nZW https://t.co/ODihw6qtsQ" /
![Moderna on X: "We have submitted a request for emergency use authorization (EUA) for our Omicron-targeting bivalent #COVID19 #vaccine, mRNA-1273.222, in children and adolescents 12 to 17 years of age to the Moderna on X: "We have submitted a request for emergency use authorization (EUA) for our Omicron-targeting bivalent #COVID19 #vaccine, mRNA-1273.222, in children and adolescents 12 to 17 years of age to the](https://pbs.twimg.com/media/FdVqwV6XkAM6Uva.jpg:large)
Moderna on X: "We have submitted a request for emergency use authorization (EUA) for our Omicron-targeting bivalent #COVID19 #vaccine, mRNA-1273.222, in children and adolescents 12 to 17 years of age to the
![Moderna on X: "A Phase 2/3 trial for mRNA-1273.222 is currently underway. We have rapidly scaled manufacturing of mRNA-1273.222 to be ready, if authorized, to deliver doses in September. https://t.co/AQG4hfwNe6" / X Moderna on X: "A Phase 2/3 trial for mRNA-1273.222 is currently underway. We have rapidly scaled manufacturing of mRNA-1273.222 to be ready, if authorized, to deliver doses in September. https://t.co/AQG4hfwNe6" / X](https://pbs.twimg.com/media/Fa3vfLMWIAMxYX1.jpg)
Moderna on X: "A Phase 2/3 trial for mRNA-1273.222 is currently underway. We have rapidly scaled manufacturing of mRNA-1273.222 to be ready, if authorized, to deliver doses in September. https://t.co/AQG4hfwNe6" / X
![Moderna says updated booster generated 'significantly higher' neutralizing antibodies against BA.4/BA.5 subvariants | CNN Moderna says updated booster generated 'significantly higher' neutralizing antibodies against BA.4/BA.5 subvariants | CNN](https://media.cnn.com/api/v1/images/stellar/prod/220811105702-moderna-vaccine-vial-illustration.jpg?c=original)
Moderna says updated booster generated 'significantly higher' neutralizing antibodies against BA.4/BA.5 subvariants | CNN
![Moderna says its Omicron shots provide better protection than original COVID-19 jab - National | Globalnews.ca Moderna says its Omicron shots provide better protection than original COVID-19 jab - National | Globalnews.ca](https://globalnews.ca/wp-content/uploads/2022/11/Moderna-Omicron.jpg?quality=85&strip=all)
Moderna says its Omicron shots provide better protection than original COVID-19 jab - National | Globalnews.ca
Moderna's BA.4/BA.5 Targeting Bivalent Booster, mRNA-1273.222, Meets Primary Endpoint of Superiority Against Omicron Variants Compared to Booster Dose of mRNA-1273 in Phase 2/3 Clinical Trial
![Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice | Nature Medicine Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice | Nature Medicine](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41591-022-02092-8/MediaObjects/41591_2022_2092_Fig1_HTML.png)